Novak Djokovic experienced a difficult start at the US Open, losing in the opening round for the first time. He faced Mariano Navone and was ultimately defeated in 5 sets. Djokovic struggled with physical and internal ailments throughout the match, compounding his difficulties with a series of mistakes.

Despite his efforts, Djokovic was unable to overcome his challenges and secure a win against Navone. The loss marked a disappointing beginning to his US Open campaign. Further details about the match are available from the source, providing more insight into Djokovic's performance and the events that unfolded during the opening round.